She was married to George O'Malley , but divorced after he cheated on her. Callie grew up in southern Florida. She was one of two daughters in a wealthy family, a fact she doesn't like to share with significant others. She has stated that "four years of high school, four years of college, four years of medical school" makes doctors socially inept at times. She has described herself as "a total freak," and "I'm that girl in the back of the class who eats her hair.